MALT1 protease activity in primary effusion lymphoma
نویسندگان
چکیده
منابع مشابه
MALT1 protease activity in primary effusion lymphoma
The activation, proliferation and survival of lymphocytes depend on the antigen receptor-induced formation of cytoplasmic signaling complexes that control specific transcriptional pathways. The protease MALT1 has an essential role in lymphocyte activation and lymphoma development [1, 2]. Upon antigen receptor triggering, MALT1 is recruited to the so-called CBM complex, formed by the assembly of...
متن کاملProtease activity of MALT1: a mystery unravelled.
Constitutive NF-κB (nuclear factor κB) activation in B-cell lymphomas relies greatly on the CARMA1 [CARD (caspase recruitment domain)-containing MAGUK (membrane-associated guanylate kinase) 1]-Bcl10-MALT1 (mucosa-associated lymphoid tissue translocation gene 1) signalling complex. Within this protein complex, MALT1 possesses a rather unique enzymatic activity, which allows it to cleave Bcl10, R...
متن کاملPrimary effusion lymphoma.
Primary effusion lymphoma (PEL) is a rare HIV-associated non-Hodgkin's lymphoma (NHL) that accounts for approximately 4% of all HIV-associated NHL. PEL has a unique clinical presentation in having a predilection for arising in body cavities such as the pleural space, pericardium, and peritoneum. PEL cells are morphologically variable with a null lymphocyte immunophenotype and evidence of human ...
متن کاملEssential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.
A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse large B-cell lymphoma (DLBCL) of the activated B-cell (ABC) subtype, the least curable subtype of DLB...
متن کاملMolecular pathways: targeting MALT1 paracaspase activity in lymphoma.
MALT1 mediates the activation of NF-κB in response to antigen receptor signaling. MALT1, in association with BCL10 and CARD11, functions as a scaffolding protein to activate the inhibitor of IκB kinase (IKK) complex. In addition, MALT1 is a paracaspase that targets key proteins in a feedback loop mediating termination of the NF-κB response, thus promoting activation of NF-κB signaling. Activate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.23693